Test your understanding

Question 1 of 10

How many recognised ‘hallmarks of cancer’ are there?

9
6
10
8

Question 2 of 10

How many DNA mutations are required for a cell to behave as a cancer cell?

1
2-20
1-5
10-20
>20

Question 3 of 10

Which of the following statements about telomeres are true?

Telomeres are stretches of DNA at the ends of chromosomes
Telomerase causes the breakdown of telomeres
Telomeres get longer with age
Shortened telomeres result in cell senescence

Question 4 of 10

What is the process that allows cancer cells to metastasize?

Angiogenesis
Apoptosis
Epithelial-mesenchymal transition
Oxidative phosphorylation

Question 5 of 10

Which of the following are tumour suppressor proteins?

Rb
P16
PI3K
PTEN

Question 6 of 10

Which of the following are ways in which tumour cells can evade the immune system?

Increased expression of proteins on cells surface
Recruitment of Tregs and myeloid derived suppressor cells
Activation of endothelial cells and fibroblasts
Expression of immune checkpoint proteins

Question 7 of 10

By which mechanism do cancer cells generate energy?

Epithelial-mesenchymal transition
Oxidative phosphorylation
Aerobic glycolysis
Angiogenesis

Question 8 of 10

Match the drug to its target

Sort elements

Vascular Endothelial Growth Factor Receptor Tyrosine Kinase
Epithelial Growth Factor Receptor
BRAF
Human Epithelial Growth Factor Receptor (HER2)
Programmed Death Receptor-1
mTOR
MEK

Sunitinib
Cetuximab
Dabrafenib
Trastuzumab
Nivolumab
Everolimus
Trametinib

Question 9 of 10

Which subtype of PI3K is commonly mutated in solid tumours?

PI3K alpha
PI3K beta
PI3K delta
PI3K gamma

Question 10 of 10

Select the correct statement relating to response to different treatment types

Sort elements

high response rate + short duration of response
higher response rate + improved duration of response
low response rate + prolonged duration of response

Cytotoxic chemotherapy
Targeted treatments
Checkpoint inhibitors

Quiz Summary

Information

Results

Results

Categories

1. Question

Question 1 of 10

2. Question

Question 2 of 10

3. Question

Question 3 of 10

4. Question

Question 4 of 10

5. Question

Question 5 of 10

6. Question

Question 6 of 10

7. Question

Question 7 of 10

8. Question

Question 8 of 10

Sort elements

9. Question

Question 9 of 10

10. Question

Question 10 of 10

Sort elements